|Overview||Rainbow Six||Rogue Spear||Raven Shield||Black Arrow||Lockdown||Vegas||Vegas 2||Siege|
|"A lot of eyes are on us this time, especially since we have poor intel."|
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- "Developed in America, this pistol chambers a very powerful .357 round making it one of Rainbow's deadliest weapons. Normally the DE 357 uses the High Capacity Magazine attachment."
— In-game description
The DE 357 is a weapon featured in Tom Clancy's Rainbow Six: Lockdown. It is only available on the PC version of the game.
In-game, the DE 357 is used by the United Fatherland Brigade in the missions Catacombs and Hospital, by the Marxist Radical Front in the missions NATO Summit and Cruise Ship, and by the Global Liberation Front in the missions Estate and Mercenary Base.